Hu Lifang

Hu Lifang

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Hu lifang, Ph.D.

Education：

2002/9-2006/6, B.S. School of Life Sciences, Shaanxi Normal University, China

2006/9-2009/3, M.D. School of Life Sciences, Northwestern Polytechnical University, China

2009/4-2013/12, Ph.D. School of Life Sciences, Northwestern Polytechnical University, China

2013/12-2015/12, Postdoc School of Life Sciences, Northwestern Polytechnical University, China

E-mail：hulifang@nwpu.edu.cn

Research Interests：The role of MACF1 (microtubule actin crosslinking factor 1) in regulating osteoblast differentiation and bone formation.

Publications：

  1. Hu Lifang, Su Peihong, Li Runzhi, Yin Chong, Zhang Yan, Shang Peng, Yang Tuanmin, Qian Airong*. Isoforms, structures, and functions of versatile spectraplakin MACF1. BMB Reports. PMID: 26521939.

  2. Hu Lifang, Su Peihong, Li Runzhi, Yan Kun, Chen Zhihao, Shang Peng, Qian Airong*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Reports. 2015, 48(10): 583-588.

  3. Hu Lifang, Li Jingbao, Qian Airong, Wang Fei, Shang Peng*. Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition. Cell Biol Int. 2015, 39(4): 364-372.

  4. Hu Lifang, Li Runzhi, Su Peihong, Arfat Yasir, Zhang Ge, Shang Peng, Qian Airong*. Response and adaptation of bone cells to simulated microgravity. Acta Astronaut, 2014, 104(1): 396-408.

  5. Hu Lifang, Qian Airong, Wang Yang, Di Shengmeng, Shang Peng*. Inhibitory effect of simulated microgravity on differentiating preosteoblasts. Adv Space Res, 2013, 51(1), 107-114.

  6. Qian Airong, Hu Lifang, Gao Xiang, Zhang Wei, Di Shengmeng, Tian Zongcheng, Yin Dachuan, Weng Yuanyuan, Shang Peng*. Large gradient high magnetic field affects the association of MACF1 with actin and microtubule cytoskeleton. Bioelectromagnetics, 2009, 30(7), 545-555.

  7. Yang Pengfei, Hu Lifang, Wang Zhe, Ding Chong, Zhang Wei, Qian Airong, Shang Peng*. Inhibitory effects of moderate static magnetic field on leukemia. IEEE T Magn. 2009, 45(5), 2136-2139.

  8. Qian Airong, Yang Pengfei, Hu Lifang, Zhang Wei, Di Shengmeng, Wang Zhe, Gao Xiang, Shang Peng*. High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton associated genes in human osteoblasts cultured in vitro. Adv Space Res, 2010, 46: 687-700.

  9. Qian Airong, Wang Liang, Gao Xiang, Zhang Wei, Hu Lifang, Han Jing, Li Jingbao, Di Shengmeng, Shang Peng*. Diamagnetic levitation causes changes in the morphology, cytoskeleton and focal adhesion proteins in osteocytes. IEEE T Bio-Med Eng. 2012, 59(1): 68-77.

  10. Hu Lifang, Qian Airong, Li Dijie, Li Jingbao, Shang Peng*. The response to high magneto-gravitational environment of different differentiating-stage osteoblasts. Chinese Journal of Cell Biology，2013, 35(7): 950-957. (In Chinese)

  11. Hu Lifang, Qian Airong, Shang Peng*. Sclerostin and bone metabolism. Chemistry of Life，2011, 31(5): 613-618. (In Chinese)

  12. Hu Lifang, Qian Airong, Shang Peng*. Role of vinculin in cell response to mechanical stimuli. Chinese Journal of Biochemistry and Molecular Biology，2009, 25(9): 805-810. (In Chinese)

  13. Hu Lifang, Qian Airong, Yang Pengfei, Zhang Wei, Xie Li, Shang Peng*. Effects of moderate static magnetic field on cell proliferation and cell cycle of leukemia cells. Journal of the Fourth Millitary Medical University，2009, 30(5): 397-400. (In Chinese)

  14. Qian Airong, Hu Lifang, Zhang Wei, Gao Xiang, Shang Peng*. Association of microtubule actin crosslinking factor 1 with cytoskeleton in osteoblast. Life Science Research，2009, 13(5): 382-387. (In Chinese)

  15. Li Jingbao, Hu Lifang, Zhang Wei, Qian Airong, Shang Peng*. Detection of cellular fibronectin by In-Cell Western. Journal of the Fourth Millitary Medical University, 2009,30(19)：1861-1863. (In Chinese)

  16. Qian Airong, Zhang Bo, Hu Lifang, Zhang Wei, Weng Yuanyuan, Gao Xiang, Shang Peng*. Bioinformatics analysis and cellular localization of microtubule actin crosslinking factor 1. Journal of the Fourth Millitary Medical University, 2009, 30(1): 33-36. (In Chinese)

Academic Conferences:

  1. Hu Lifang, Su Peihong, Li Runzhi, Yin Chong, Yan Kun, Zhang Ge, Shang Peng, Airong Qian*. A novel role of MACF1: positively regulates osteoblast differentiation. ASBMR 2015 Annual Meeting, Seattle, USA, Oct. 9-12, 2015.

  2. Hu Lifang, Su Peihong, Li Runzhi, Yin Chong, Yan Kun, Zhang Ge, Shang Peng, Airong Qian*. The role of MACF1 in regulating osteoblast differentiation. The International Chinese Musculoskeletal Research Society (ICMRS) Conference and Xiangya Osteoporosis Forum, Changsha, China. 2015, April 9-11.

  3. Hu Lifang, Qian Airong, Wang Yang, Di Shengmeng, Shang Peng*. The inhibitory effect on differentiation of osteoblasts cultured on random positioning machine, 5th China-Germany Workshop on Microgravity and Space Life Sciences, Munich, Germany, Sep. 10-14, 2012.

  4. Hu Lifang, Li Runzhi, Su Peihong, Arfat Yasir, Zhang Ge, Shang Peng, Qian Airong*. Response and adaptation of bone cells to simulated microgravity. 2014 Annual Meeting of Shaanxi Society of Cell Biology，Xianyang, Shaanxi, China, 2014.11.7-9.

Funds:

  1. Natural Science Foundation of China (NSFC): “The role of MACF1 in simulated weightlessness inhibiting osteoblast differentiation through regulating Wnt/β-catenin signaling”(No. 31400725), 2015.1~2017.12, Project Director

  2. Project Funded by China Postdoctoral Science Foundation (Key Program): “The role and mechanism of miR-138-5p in simulated weightlessness inhibiting bone formation”(No. 2015T81051), 2015.9~2017.9, Project Director

  3. Project Funded by China Postdoctoral Science Foundation: “Study on the role of MACF1 in simulated weightlessness inhibiting bone formation”(No. 2014M562450), 2014.9~2015.12, Project Director

  4. Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China:   “The role of MACF1 in simulated weightlessness affecting preosteoblast migration”(No. 2015JQ3076), 2015.1~2016.12, Project Director

  5. Fundamental Research Funds for the Central Universities: “Study on the molecular mechanism of preosteoblast migration to bone formation surface”(No. 3102014JKY15007), 2014.5~2016.5, Project Director

  6. Undergraduate Innovative Training Program: “Identification of genotype and phenotype of MACF1 gene knockout mice”(No. 201510699284), 2015.6~2016.6, Adviser

Patents:

  1. Qian Airong, Shang Peng, Hu Lifang, Li Runzhi, Su Peihong, Yin Chong, Yan Kun, Chen Zhihao, Qi Yiduo, Sun Yulong. The shRNA sequence for inhibiting murine MACF1 expression and its application. CN 104531700A.

Awards:

  1. Outstanding Paper Award for Young Scientists, 2014, The Committee on Space Research (COSPAR)

  2. Third Prize of Outstanding Paper for Young Scientists, 2014, Shaanxi Society of Cell Biology